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It is apparent from many of the posts
on this Web Site as well as messages to other CML discussion groups on the
Web, that many Gleevec patients are being treated by Doctors who are not
familiar with the proper procedures for using this drug. Gleevec is a new
drug and there are only a few Doctors who have had experience with its
proper use. Also, CML (Chronic Myelogenous Leukemia) is a relatively rare
form of cancer which most Doctors have had very little experience in
treating. These factors have lead to a concern in the medical community that
some patients might be harmed by lack of proper management of their disease.
Some of the concerns expressed by the experts are:
1. Dose management...Some patients are being prescribed
either too low a dose which could contribute to the development of
resistance to Gleevec or to high a dose which could result unacceptable
toxicity.
2. Monitoring Blood Chemistries...Some patients are not having the
necessary blood tests at the proper frequency to monitor the side effects
of Gleevec.
3. Cytogenetic and Molecular Testing...Some patients are not being closely
monitored with regular cytogenetic and molecular tests on their bone
marrow which allow the Physician to access the stage of their disease and
make treatment decisions.
Patients should seek Doctors who have had experience and
training in the treatment of CML with Gleevec. Gleevec was approved for
prescription sale in the United States on May 10, 2001, therefore the only
Doctors who have appreciable experience are at the major cancer treatment
centers which participated in the clinical trials of Gleevec. Patients
should seek treatment from one of these centers. Patients who do not live
near one of these centers may elect to have their routine visits for lab
work done at their local Doctors office and fax the results to their primary
Physician at the major cancer center. Generally, patients need to return to
the primary treatment center only every 3 to 6 months so this should not be
a problem for most patients.
Below, is a partial list of Doctors and contacts who have extensive
experience in treating CML with Gleevec. This is not complete list. There
are many qualified Doctors and institutions which do not appear here. This
list is all I have at this time. I will add Doctors and institutions as the
information becomes available to me. |
Below, is a list of North America Trial Centers...sorted by Country,
State/Province then City.
| Center |
Address |
Country |
City |
State |
Zip |
Contact |
Phone |
Fax |
Email |
|
McMaster University Hospital |
1200 Main St. W. |
Canada |
Hamilton |
Ontario |
L8N 3Z5 |
Irwin R. Walker, M.D. |
(905) 521-2100 |
|
None |
| Ottawa
General Hospital |
501 Chemin Smyth Road |
Canada |
Ottawa |
Ontario |
K1H 8L6 |
Isabelle Bence-Bruckler, M.D. |
(613) 737-8152 |
|
None |
|
Princess Margaret Hospital |
Bell Wing 1-651 585 University Avenue |
Canada |
Toronto |
Ontario |
M5G 2C4 |
Dr. Keating |
(416) 340-3303 |
(416) 340-4896 |
None |
|
Jonsson
Comprehensive Cancer Center at UCLA |
8-684 Factor Building |
USA |
Los Angeles, |
California |
90095-1781 |
Ronald Paquette, M.D. |
(310) 825-5608 |
|
paquette@ucla.edu |
|
Stanford
University Medical Center |
300 Pasteur Drive, Hematology Clinic, Rm. A-174
|
USA |
Palo Alto |
California |
94304 |
Steven E. Coutre, M.D. |
(650) 723-9729 (Nurse Lenn Fechter) (650) 736-1009
|
(650) 498-4249 (Nurse Lenn Fechter) (650) 723-1269
|
coutre@leland.stanford.edu |
|
University of Miami Sylvester Comprehensive Cancer Center |
1475 N.W. 12th Avenue, Room 4023 |
USA |
Miami, |
Florida |
33136 |
Kapil Bhalla, M.D. |
(305) 243-5907 |
|
kbhalla@med.miami.edu |
| H.
Lee Moffitt Cancer Center & Research Institute At The University of South
Florida |
12902 Magnolia Dr. |
USA |
Tampa, |
Florida |
33612 |
Thomas P. Loughran, Jr. M.D. |
(813) 903-6841 (Nurse Denise Cosgrove) (813) 979-3058
|
(813) 979-6700 (Nurse Denise Cosgrove) (813) 979-6732
|
loughrat@moffitt.usf.edu |
|
Northwestern Memorial Hospital |
675 N. St. Claire Street |
USA |
Chicago, |
Illinois |
60611 |
Martin S. Tallman, M.D. |
(312) 695-8697 |
(312) 695 4844 |
m-tallman@nwu.edu
|
|
Johns
Hopkins Oncology Center |
600 North Wolfe Street |
USA |
Baltimore, |
Maryland |
21287-8943 |
Carole B. Miller, M.D. |
(410) 955-8603 |
(410) 614-9250 |
carole.miller@jhu.edu
|
|
University of Maryland Greenebaum Cancer Center |
22 South Greene Street |
USA |
Baltimore, |
Maryland |
21201 |
Dr. Stanley R. Frankel |
(410) 328-1230 |
(410) 328-1975 |
sfrankel@umcc01.ab.umd.edu |
|
Harvard University Dana-Farber Cancer Institute |
44 Binney St., D1740 |
USA |
Boston, |
Massachusetts |
02115 |
Richard M. Stone, M.D. |
(617) 632-2214 |
(617) 632-2933 |
rstone@partners.org
|
|
University of Michigan Comprehensive Cancer Center |
1500 East Medical Center Drive |
USA |
Ann Arbor |
Michigan |
48109 |
Moshe Talpaz, M.D.
|
(734) 764-8195 |
(734) 647-9654 |
mtalpaz@umich.edu |
|
Barbara Ann Karmanos Cancer Institute |
4100 John R. Street |
USA |
Detroit, |
Michigan |
48201 |
Charles Alan Schiffer, M.D. |
(313) 745-8910 |
(313) 993-0559 |
schiffer@karmanos.org |
|
New York Presbyterian Hospital |
525 East 68th Street |
USA |
New York, |
New York |
10021 |
Nikki Polidori |
(212) 288-5040 |
(212) 427-6012 |
None |
| Oregon
Health Sciences University L592 |
3181 S. West Sam Jackson Park Road |
USA |
Portland, |
Oregon |
97201-3098 |
Brian
J. Druker, M.D. (Principal Investigator) |
(503) 494-5596 |
(503) 494-3688 |
drukerb@ohsu.edu
|
|
University of Texas M. D. Anderson Cancer Center |
1515 Holcombe Blvd., Box 302 |
USA |
Houston, |
Texas |
77030-4095 |
Hagop Kantarjian, M.D. |
(713) 792-7026 |
|
mtalpaz@notes.mdacc.tmc.edu |
| Huntsman Cancer Institute at the University of Utah
|
2000 Circle of Hope |
USA |
Salt Lake City |
Utah |
84112 |
Gina Gregovich |
(801) 581-4477 |
|
gina.gregovich@hci.utah.edu |
Below, is a list of United Kingdom Trial Centers...sorted by City.
| Contact name(s) |
Address |
Phone |
Fax |
|
Dr Stephen O'Brien
Dr Anne Lennard |
Department of Haematology,
University of Newcastle, Royal Victoria Infirmary, Newcastle, NE1 4LP, UK |
(+44) 191 282 4743 |
(+44) 191 201 0154 |
|
Prof John Goldman |
Department of Haematology,
Hammersmith Hospital, Du Cane Road London W12 0NN |
(+44) 20 8383 3238 |
(+44) 20 8740 9679 |
|
Dr Simon Rule |
Department of Haematology,
Derriford Hospital, Derriford Road Plymouth PL6 8DH. |
(+44) 1752 517505 |
(+44) 1752 792400 |
|
Dr Donald Milligan |
Department of Haematology,
Birmingham Heartlands Hospital, Birmingham B9 5ST. |
(+44) 121 766 6611 ext 4272 |
(+44) 121 766 7530 |
|
Dr Tessa Holyoake |
ATMU, Department of Medicine,
Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER |
(+44) 141 211 1202 |
(+44) 141 211 0414 |
|
Dr Guy
Lucas |
Department of Haematology,
Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL |
(+44) 161 276 4813 |
(+44) 161 276 4814 |
| Dr Richard Clark |
Royal Liverpool University
Hospital, Prescot Street, Liverpool L7 8XP |
(+44) 151 706 4344 |
(+44) 151 706 5810 |
|
Prof Ghulam Mufti |
Department of Haematological
Medicine, King's College Hospital, Denmark Hill, London, SE5 9RS |
(+44) 20 7346 3080 |
(+44) 20 7346 3516 |
|
Prof Shaun McCann |
Dept of Haematology, St James
Hospital, Dublin 8 Ireland |
(+353) 1 416 2166 |
(+353) 1 410 3476 |
Below, is a list of Novartis World wide contact numbers for information
on Gleevec (STI571) Trials...sorted by country.
| Country |
Contact |
Phone |
| Australia |
Sue Cairns |
61-2-9805-3555 |
| Austria |
Gerfrie Nell |
43-1-86657 |
| Belgium |
Michael Geelhand |
32-2-24-61-611 |
| Canada |
Diane Bluteau |
(514) 631-6775 |
| Denmark |
Kim Simonsen |
45-39-168-400 |
| Far East |
Drummond Paris |
65-22-36963 |
| Finland |
Kari Harjula |
35-89-61-33-2211 |
| France |
Patrice Berthaud or Annick Roche |
33-154-76000 |
| Germany |
Rolf Ihrig |
49-911-273-12462 |
| Greece |
Eleni Boutati |
30-1-28-11-712 |
| Ireland |
John French |
35-31-260-1255 |
| Israel |
Savion Gropper |
972-3-922-9244-115 |
| Italy |
Danielle Alberti |
39-02-9-654-2817 |
| Latin America |
Enrique Isola |
54-11-4703-7000 |
| New Zealand |
Sean Evans |
64-9-828-3149 |
| Norway |
Dag Solbu |
47-23-05-2000 |
| Peru |
Eduardo Parodi |
51-1-494-2673 |
| Portugal |
Pedro Freitas |
35-1-21-92-68-600 |
| Sweden |
Per Anderson |
46-8-73-23-210 |
| Switzerland |
Joan Gloor |
41-31-377-5352 |
| UK |
Val Allsup |
44-1276-698-260 |
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